Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …
aroused great interest in medicinal chemists for the development of new drugs or drug …
Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological …
Nitrogen-rich heterocycles, particularly quinazolines and quinazolinones, represent a
unique class of diversified frameworks displaying a broad spectrum of biological functions …
unique class of diversified frameworks displaying a broad spectrum of biological functions …
Design and synthesis of novel quinazolinone-1, 2, 3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study
M Saeedi, M Mohammadi-Khanaposhtani… - Bioorganic …, 2019 - Elsevier
A novel series of quinazolinone-1, 2, 3-triazole hybrids 10a-p were designed, synthesized,
and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti …
and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti …
Recent advances in synthetic α‐glucosidase inhibitors
Z Liu, S Ma - ChemMedChem, 2017 - Wiley Online Library
Over the past few years, the number of people diagnosed with type 2 diabetes has
increased owing to an unhealthy diet, a limited amount of exercise, and obesity. The search …
increased owing to an unhealthy diet, a limited amount of exercise, and obesity. The search …
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review
Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …
incidences are reported annually. Heterocyclic compounds have been proved to be very …
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Design and synthesis of new benzylidene-quinazolinone hybrids as potential anti-diabetic agents: In vitro α-glucosidase inhibition, and docking studies
MM Khalifa, HM Sakr, A Ibrahim, AM Mansour… - Journal of Molecular …, 2022 - Elsevier
A novel series of benzylidene-quinazolinone hybrids 8 a, b and 10 an were designed,
synthesized, and evaluated for their in vitro α-glucosidase inhibitory effect aiming to discover …
synthesized, and evaluated for their in vitro α-glucosidase inhibitory effect aiming to discover …
Imidazo[1,2-c]quinazolines as a novel and potent scaffold of α-glucosidase inhibitors: design, synthesis, biological evaluations, and in silico studies
F Peytam, F Hosseini, M Hekmati, B Bayati… - Scientific Reports, 2023 - nature.com
Abstract α-Glucosidase inhibition is an approved treatment for type 2 diabetes mellitus
(T2DM). In an attempt to develop novel anti-α-glucosidase agents, two series of substituted …
(T2DM). In an attempt to develop novel anti-α-glucosidase agents, two series of substituted …
Synthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1H)-ones Derived from Pyrazol-4 …
A Barmak, K Niknam, G Mohebbi - ACS omega, 2019 - ACS Publications
A series of new quinazoline derivatives were designed and synthesized via a one-pot
condensation reaction between isatoic anhydride and aromatic aldehydes with anilines …
condensation reaction between isatoic anhydride and aromatic aldehydes with anilines …
Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study
Previously, we synthesized triazoloquinazolines 1–14 and characterized their structure. In
this study, we aimed to evaluate the in vitro activity of the targets 1–14 as α-glucosidase …
this study, we aimed to evaluate the in vitro activity of the targets 1–14 as α-glucosidase …