Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …

Obesity is increasing in an alarming rate worldwide, which causes higher risks of some
diseases, such as type 2 diabetes, cardiovascular diseases, and cancer. Current therapeutic …

Almost 20 years ago, the protein encoded by the ob locus in mice was identified as an
adipocyte-secreted hormone, now termed leptin, which functions as a peripheral signal to …

Sterol metabolites are critical signaling molecules that regulate metabolism, development,
and homeostasis. Oxysterols, bile acids (BAs), and steroids work primarily through cognate …

Obesity is caused by an imbalance between energy intake and energy expenditure. It is
established that obesity is a state of low-grade chronic inflammation, which is characterized …

Liver X receptors (LXRs) are members of the nuclear receptor family and are present in two
isoforms, α and β, encoded by two separate genes. Originally described in the liver, LXRs …

OBJECTIVE We examined the effect of β-adrenergic receptor (βAR) activation and cAMP-
elevating agents on respiration and mitochondrial uncoupling in human adipocytes and …

Non-alcoholic fatty liver disease (NAFLD) refers to a range of conditions in which excess
lipids accumulate in the liver, possibly leading to serious hepatic manifestations such as …

The aim of the present study was to examine whether pretreatment with different fatty acids,
as well as the liver X receptor (LXR) agonist T0901317, could modify metabolic switching of …