Preclinical development in radiopharmaceutical therapy for prostate cancer

S Alati, R Singh, MG Pomper, SP Rowe… - Seminars in Nuclear …, 2023 - Elsevier
Prostate cancer is a leading cause of cancer death in men worldwide. Among the various
treatment options, radiopharmaceutical therapy has shown notable success in metastatic …

Pharmacological optimization of PSMA-based radioligand therapy

S van der Gaag, IH Bartelink, AN Vis, GL Burchell… - Biomedicines, 2022 - mdpi.com
Prostate cancer (PCa) is the most common malignancy in men of middle and older age. The
standard treatment strategy for PCa ranges from active surveillance in low-grade, localized …

Patient outcomes following a response biomarker-guided approach to treatment using 177Lu-PSMA-I&T in men with metastatic castrate-resistant prostate cancer (Re …

L Emmett, N John, S Pathmanandavel… - Therapeutic …, 2023 - journals.sagepub.com
Background: 177LuPSMA is an effective treatment in metastatic castrate-resistant prostate
cancer with trials adopting a standardised dose interval. Adjusting treatment intervals …

Towards Improving the Efficacy of PSMA-Targeting Radionuclide Therapy for Late-Stage Prostate Cancer—Combination Strategies

D Arbuznikova, M Eder, AL Grosu, PT Meyer… - Current Oncology …, 2023 - Springer
Abstract Purpose of Review [177Lu] Lu-PSMA-617 is a radiopharmaceutical that emits beta-
minus radiation and targets prostate-specific membrane antigen (PSMA)-positive prostate …

Understanding the Radiobiological Mechanisms Induced by 177Lu-DOTATATE in Comparison to External Beam Radiation Therapy

W Delbart, J Karabet, G Marin, S Penninckx… - International journal of …, 2022 - mdpi.com
Radionuclide Therapy (RNT) with 177Lu-DOTATATE targeting somatostatin receptors
(SSTRs) in neuroendocrine tumours (NET) has been successfully used in routine clinical …

DNA damage by radiopharmaceuticals and mechanisms of cellular repair

Y Khazaei Monfared, P Heidari, SJ Klempner… - Pharmaceutics, 2023 - mdpi.com
DNA is an organic molecule that is highly vulnerable to chemical alterations and breaks
caused by both internal and external factors. Cells possess complex and advanced …

In vivo efficacy testing of peptide receptor radionuclide therapy radiosensitization using Olaparib

D Feijtel, TGA Reuvers, C van Tuyll-van Serooskerken… - Cancers, 2023 - mdpi.com
Simple Summary Neuroendocrine tumor (NET) patients often suffer from metastases,
thereby eliminating surgery as a curative treatment option. A possible treatment strategy for …

[HTML][HTML] Selective ablation of TRA-1-60+ pluripotent stem cells suppresses tumor growth of prostate cancer

JM White, N Ramos, AD Saliganan, JY Chung… - Theranostics, 2023 - ncbi.nlm.nih.gov
Purpose: TRA-1-60 (TRA) is an established transcription factor of embryonic signaling and a
well-known marker of pluripotency. It has been implicated in tumorigenesis and metastases …

Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method

Z Talebi, DA Garrison, ED Eisenmann, K Parmar… - Heliyon, 2023 - cell.com
A rapid, sensitive, and simple UHPLC-MS/MS method for the determination of the PARP
inhibitor talazoparib in mouse plasma was developed and validated using [13 C, 2 H 4] …

[HTML][HTML] Multidisciplinary team approach in prostate-specific membrane antigen theranostics for prostate cancer: a narrative review

M Suh, GJ Cheon - Journal of Urologic Oncology, 2024 - e-juo.org
In managing prostate cancer, the integration of multidisciplinary team (MDT) with prostate-
specific membrane antigen (PSMA) theranostics marks a significant advancement …