Pyrazoline derivatives as promising MAO-A targeting antidepressants: an update
Depression is one of the key conditions addressed by the Mental Health Gap Action
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is …
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is …
Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies
Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably
depression), presenting it as a significant therapeutic target for treating such conditions …
depression), presenting it as a significant therapeutic target for treating such conditions …
Natural flavonoids as promising lactate dehydrogenase A inhibitors: Comprehensive in vitro and in silico analysis
Ü Yırtıcı - Archiv der Pharmazie, 2024 - Wiley Online Library
The inhibitory potential of 17 flavonoids on lactate dehydrogenase A (LDHA), a key enzyme
in the downstream process of aerobic glycolysis in cancer cells, is investigated. Fisetin …
in the downstream process of aerobic glycolysis in cancer cells, is investigated. Fisetin …
Pyrrole: An Essential Framework in the Development of Therapeutic Agents and Insightful Analysis of Structure‐Active Relationships
B Sahu, R Sahu, B Gidwani, A Mishra - ChemistrySelect, 2024 - Wiley Online Library
Pyrrole is a heterocyclic structure with diverse pharmacophores, enabling the creation of an
extensive lead molecule library. Its broad range of pharmacological profiles has concerned …
extensive lead molecule library. Its broad range of pharmacological profiles has concerned …
Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway
H Zhou, M Li, H Liu, Z Liu, X Wang… - Journal of Enzyme …, 2024 - Taylor & Francis
In this study, four series of piperazine derivatives were designed, synthesised and subjected
to biological test, and compound 6a with potential antidepressant activity was obtained. An …
to biological test, and compound 6a with potential antidepressant activity was obtained. An …
Design, synthesis, and biological evaluation of 1, 2, 4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents
MS Ayoup, MR Barakat, H Abdel-Hamid… - RSC Medicinal …, 2024 - pubs.rsc.org
A series of novel 1, 2, 4-oxadiazole-based derivatives were synthesized and evaluated for
their potential anti-Alzheimer disease activity. The results revealed that compounds 2b, 2c …
their potential anti-Alzheimer disease activity. The results revealed that compounds 2b, 2c …
Identification of novel DNA gyrase inhibitor by combined pharmacophore modeling, QSAR analysis, molecular docking, molecular dynamics, ADMET and DFT …
A Moulishankar, M Sankaranarayanan… - Acta Tropica, 2024 - Elsevier
DNA gyrase, an ATP-dependent enzyme, plays a critical role in DNA replication,
transcription, and recombination in Mycobacterium tuberculosis (MTB). While …
transcription, and recombination in Mycobacterium tuberculosis (MTB). While …
Exploration of oxadiazole clubbed benzhydrylpiperazine pharmacophoric features as structural feature for antidepressant activity: In vitro, in vivo and in silico analysis
Arylpiperazine clubbed various heterocyclic molecules present potential pharmacophoric
structural features for the development of psychoactive drugs. There are various CNS active …
structural features for the development of psychoactive drugs. There are various CNS active …
Prediction of ESR1 Network and Molecular Modeling Analysis of Bioactive Molecules from Ficus microcarpa Targeting ER-alpha for Breast Cancer Therapy
Ficus microcarpa L. f. is a common tree found in India, as well as South, Southeast, and East
Asia, and is known locally as Kallichi maram (Tamil). The major phytochemicals from F …
Asia, and is known locally as Kallichi maram (Tamil). The major phytochemicals from F …
Formulate Lornoxicam Bio Adhesive Microspheres Using Different Polymers by Ionotropic Gelation Method and Emulsion Cross Linking Method: An Integrated …
Background Lornoxicam microspheres are promising for targeted, controlled, or extended
drug release, and the incorporation of mucoadhesive properties can significantly enhance …
drug release, and the incorporation of mucoadhesive properties can significantly enhance …