Death by ribosome
Next to their essential role as protein production factories, ribosomes serve as molecular
sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling …
sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling …
Legionella pneumophila, a Rosetta stone to understanding bacterial pathogenesis
KA Romanov, TJ O'Connor - Journal of Bacteriology, 2024 - journals.asm.org
Legionella pneumophila is an environmentally acquired pathogen that causes respiratory
disease in humans. While the discovery of L. pneumophila is relatively recent compared to …
disease in humans. While the discovery of L. pneumophila is relatively recent compared to …
Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors
DT Patel, PJ Stogios, L Jaroszewski… - Molecular Systems …, 2025 - embopress.org
Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …
Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex
Under stress conditions, translationally stalled mRNA and associated proteins undergo
liquid-liquid phase separation and condense into cytoplasmic foci called stress granules …
liquid-liquid phase separation and condense into cytoplasmic foci called stress granules …
The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT
The eukaryotic CCR4− NOT deadenylase complex is a highly conserved regulator of mRNA
metabolism that influences the expression of the complete transcriptome, representing a …
metabolism that influences the expression of the complete transcriptome, representing a …
Insights into the role of legionella effectors on host metabolic perturbations
Z Wang, L Song, J Che, C Li - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
Legionella infection, the causative agent of Legionnaires' disease, represents a significant
threat to human health. The pathogenesis of this infection is intricately linked to the complex …
threat to human health. The pathogenesis of this infection is intricately linked to the complex …
[HTML][HTML] An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation
W Xian, Z Tang, Q Zhang, Y Wang, X Liu - Toxins, 2024 - mdpi.com
Post-translational modifications (PTMs) are increasingly recognized as important strategies
used by bacterial pathogens to modulate host cellular functions. Protein ADP-riboxanation, a …
used by bacterial pathogens to modulate host cellular functions. Protein ADP-riboxanation, a …
Molecular mimicry sweetens the deal for MANagement of host mRNA translation and stress responses by Legionella pneumophila
SR Shames - Molecular Cell, 2024 - cell.com
The Legionella pneumophila effector SidI inhibits host mRNA translation and must be
regulated for intracellular replication. Subramanian et al. 1 reveal the mechanism of SidI …
regulated for intracellular replication. Subramanian et al. 1 reveal the mechanism of SidI …
Origin of ribonucleotide recognition motifs through ligand mimicry at early earth
D Mozumdar, RN Roy - RNA biology, 2024 - Taylor & Francis
In an RNA world, the emergence of template-specific self-replication and catalysis
necessitated the presence of motifs facilitating reliable recognition between RNA molecules …
necessitated the presence of motifs facilitating reliable recognition between RNA molecules …
Sense codon-misassociated eRF1 elicits widespread ribosome stalling and induction of quality control
Ribosome-associated quality control (RQC) is a surveillance system for aberrant translation
that senses ribosome collisions. Although the molecular mechanism has been extensively …
that senses ribosome collisions. Although the molecular mechanism has been extensively …