Natural compounds that target microtubules and disrupt the normal function of the mitotic
spindle have proven to be one of the best classes of cancer chemotherapeutic drugs …

Vinca alkaloids have been approved as anticancer drugs for more than 50 years. They have
been classified as cytotoxic chemotherapy drugs that act during cellular mitosis, enabling …

Background Restenosis after coronary stenting necessitates repeated percutaneous or
surgical revascularization procedures. The delivery of paclitaxel to the site of vascular injury …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

Although rare, stent thrombosis remains a severe complication after stent implantation owing
to its high morbidity and mortality. Since the introduction of drug-eluting stents (DES), most …

BACKGROUND Compelling evidence indicates that paclitaxel kills cancer cells through the
induction of apoptosis. Paclitaxel binds microtubules and causes kinetic suppression …

Cell death is an essential phenomenon in normal development and homeostasis, but also
plays a crucial role in various pathologies. Our understanding of the molecular mechanisms …

Multiple signal transduction pathways are capable of modifying BCL-2 family members to
reset susceptibility to apoptosis. We used two-dimensional peptide mapping and …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …

The Akt family of serine/threonine-directed kinases promotes cellular survival in part by
phosphorylating and inhibiting death-inducing proteins. Here we describe a novel functional …