Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies
The retina and brain share similar neurochemistry and neurodevelopmental origins, with the
retina, often viewed as a “window to the brain.” With retinal measures of structure and …
retina, often viewed as a “window to the brain.” With retinal measures of structure and …
Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment
SR Kesler, AM Henneghan, S Prinsloo, O Palesh… - Frontiers in …, 2023 - frontiersin.org
Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its
treatments, yet the present binary diagnostic approach fails to capture the full spectrum of …
treatments, yet the present binary diagnostic approach fails to capture the full spectrum of …
Two distinct trajectories of clinical and neurodegeneration events in Parkinson's disease
Increasing evidence suggests that Parkinson's disease (PD) exhibits disparate spatial and
temporal patterns of progression. Here we used a machine-learning technique—Subtype …
temporal patterns of progression. Here we used a machine-learning technique—Subtype …
Two subtypes of schizophrenia identified by an individual-level atypical pattern of tensor-based morphometric measurement
Difficulties in parsing the multiaspect heterogeneity of schizophrenia (SCZ) based on current
nosology highlight the need to subtype SCZ using objective biomarkers. Here, utilizing a …
nosology highlight the need to subtype SCZ using objective biomarkers. Here, utilizing a …
Artificial intelligence-based clustering and characterization of Parkinson's disease trajectories
Parkinson's disease (PD) is a highly heterogeneous disease both with respect to arising
symptoms and its progression over time. This hampers the design of disease modifying trials …
symptoms and its progression over time. This hampers the design of disease modifying trials …
Magnetic resonance imaging studies of neurodegenerative disease: from methods to translational research
P Huang, M Zhang - Neuroscience Bulletin, 2023 - Springer
Neurodegenerative diseases (NDs) have become a significant threat to an aging human
society. Numerous studies have been conducted in the past decades to clarify their …
society. Numerous studies have been conducted in the past decades to clarify their …
Deep phenotyping for precision medicine in Parkinson's disease
AK Schalkamp, N Rahman… - Disease Models & …, 2022 - journals.biologists.com
ABSTRACT A major challenge in medical genomics is to understand why individuals with
the same disorder have different clinical symptoms and why those who carry the same …
the same disorder have different clinical symptoms and why those who carry the same …
The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study
CB Stewart, D Ledingham, VK Foster… - Frontiers in …, 2023 - frontiersin.org
Background Autonomic dysfunction, including gastrointestinal, cardiovascular, and urinary
dysfunction, is often present in early Parkinson's Disease (PD). However, the knowledge of …
dysfunction, is often present in early Parkinson's Disease (PD). However, the knowledge of …
Dopamine depletion and subcortical dysfunction disrupt cortical synchronization and metastability affecting cognitive function in Parkinson's disease
Parkinson's disease (PD) is primarily characterized by the loss of dopaminergic cells and
atrophy in subcortical regions. However, the impact of these pathological changes on large …
atrophy in subcortical regions. However, the impact of these pathological changes on large …
Association of structural measurements of brain reserve with motor progression in patients with Parkinson disease
Background and Objectives To investigate the relationship between baseline structural
measurements of brain reserve and clinical progression in Parkinson disease (PD). To …
measurements of brain reserve and clinical progression in Parkinson disease (PD). To …