The neurobiological basis of narcolepsy
CE Mahoney, A Cogswell, IJ Koralnik… - Nature Reviews …, 2019 - nature.com
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
Narcolepsy with cataplexy
Narcolepsy with cataplexy is a disabling sleep disorder affecting 0· 02% of adults worldwide.
It is characterised by severe, irresistible daytime sleepiness and sudden loss of muscle tone …
It is characterised by severe, irresistible daytime sleepiness and sudden loss of muscle tone …
Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin)
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …
Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl] …
CD Cox, MJ Breslin, DB Whitman… - Journal of medicinal …, 2010 - ACS Publications
Despite increased understanding of the biological basis for sleep control in the brain, few
novel mechanisms for the treatment of insomnia have been identified in recent years. One …
novel mechanisms for the treatment of insomnia have been identified in recent years. One …
Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy
TC Thannickal, R Nienhuis, JM Siegel - Sleep, 2009 - academic.oup.com
Abstract Study Objectives: Narcolepsy with cataplexy is characterized by a loss of
approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of …
approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of …
To eat or to sleep: That is a lateral hypothalamic question
E Arrigoni, MJS Chee, PM Fuller - Neuropharmacology, 2019 - Elsevier
The lateral hypothalamus (LH) is a functionally and anatomically complex brain region that
is involved in the regulation of many behavioral and physiological processes including …
is involved in the regulation of many behavioral and physiological processes including …
Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy
TC Thannickal, J John, L Shan, DF Swaab… - Science translational …, 2018 - science.org
The changes in brain function that perpetuate opiate addiction are unclear. In our studies of
human narcolepsy, a disease caused by loss of immunohistochemically detected hypocretin …
human narcolepsy, a disease caused by loss of immunohistochemically detected hypocretin …
Challenges in diagnosing narcolepsy without cataplexy: a consensus statement
Background: Diagnosing narcolepsy without cataplexy is often a challenge as the symptoms
are nonspecific, current diagnostic tests are limited, and there are no useful biomarkers. In …
are nonspecific, current diagnostic tests are limited, and there are no useful biomarkers. In …