Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …

A library of pyridine-based 1, 2, 4-triazolo-tethered indole conjugates were designed,
synthesized, and evaluated for anti-proliferative activity against a panel of six human cancer …

The present study assessed the effects of the tankyrase (TNKS) small molecule inhibitor
XAV939 on the proliferation and migration of lung adenocarcinoma A549 cells and the …

Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as
human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions …

Tankyrases 1 and 2 (TNKS1/2) are promising pharmacological targets that recently gained
interest for anticancer therapy in Wnt pathway dependent tumors. 2-Aryl-quinazolinones …

Simple Summary Colorectal cancer is the third leading cause of cancer death globally. As
well as the adverse health implications for the individual, there are also considerable …

Tankyrase is part of poly (ADP-ribose) polymerase superfamily required for numerous
cellular and molecular processes. Tankyrase inhibition negatively regulates Wnt pathway …

Recently, the combination of chemotherapy plus nivolumab (chemo-immunotherapy) has
become the standard of care for advanced-stage gastric cancer (GC) patients. However …