General anesthetics are commonly used in major surgery. To achieve the depth of
anesthesia for surgery, patients are being subjected to a variety of general anesthetics …

In designing the anaesthetic plan for patients undergoing surgery, the choice of anaesthetic
agent may often appear irrelevant and the best results obtained by the use of a technique or …

Hypoxic ischemic encephalopathy (HIE) is a serious birth complication affecting full-term
infants; 40% to 60% of affected infants die by 2 years old or have severe disabilities. Most …

Background and Purpose—Hypoxic/ischemic (HI) brain injury affects 1 to 6 per 1000 live
human births, with a mortality of 15% to 20%. A quarter of survivors have permanent …

Growing and consistent preclinical evidence, combined with early clinical epidemiological
observations, suggest potentially neurotoxic effects of commonly used anesthetic agents in …

Methods A systematic PubMed search up to June 2011 was undertaken to identify
medications with evidence of neuroprotection in pre-clinical studies when given either …

Perinatal brain injury at term is common and often manifests with neonatal encephalopathy
including seizures. The most common aetiologies are hypoxic–ischaemic encephalopathy …

Objective To investigate whether inhaling 50% xenon during hypothermia (HT) offers better
neuroprotection than xenon or HT alone. Methods Ninety‐eight newborn pigs underwent a …

Oxidative stress is implicated in the pathogenesis of many diseases; however, currently
used antioxidants have a high toxicity that constrains administration to a narrow window of …

Hypothermia (HT) improves outcome after neonatal hypoxia–ischemia. Combination therapy
may extend neuroprotection. The noble anesthetic gas xenon (Xe) has an excellent safety …