The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Glucocorticoids are steroid hormones regulated in a circadian and stress-associated
manner to maintain various metabolic and homeostatic functions that are necessary for life …

Abbreviations: AASLD, American Association for the Study of Liver Diseases; AI, artificial
intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the global obesity
and metabolic disease epidemic and is rapidly becoming the leading cause of liver cirrhosis …

Perturbation of circadian rhythmicity in mammals, either by environmental influences such
as shiftwork or by genetic manipulation, has been associated with metabolic disturbance …

The glucocorticoid receptor (GR) is a potent metabolic regulator and a major drug target.
While GR is known to play integral roles in circadian biology, its rhythmic genomic actions …

The liver is a multitasking organ with essential functions for vertebrate health spanning
metabolism and immunity. In contrast to mammals, our understanding of liver cellular …

Background & Aims Prolactin (PRL) is a multifunctional polypeptide with effects on
metabolism, however, little is known about its effect on hepatic steatosis and lipid …

NRF2 (nuclear factor erythroid 2-related factor 2) is a key transcriptional activator that
mediates the inducible expression of antioxidant genes. NRF2 is normally ubiquitinated by …

Our immune system has evolved as a complex network of cells and tissues tasked with
maintaining host homeostasis. This is evident during the inflammatory responses elicited …