The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage
and regulated release of calcium and as the entrance to the secretory pathway. Protein …

The combination of relative nutrient deprivation and dysregulation of protein synthesis make
malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which …

Cancer cells induce a set of adaptive response pathways to survive in the face of stressors
due to inadequate vascularization. One such adaptive pathway is the unfolded protein …

The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular
functions including protein folding and maturation and the maintenance of cellular …

Cancer progression is characterized by rapidly proliferating cancer cells that are in need of
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …

IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that
culminate in the sequence-specific splicing of the Xbp1 mRNA and in the regulated …

Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …

Accumulating data indicates that following anti-cancer treatments, cancer cell death can be
perceived as immunogenic or tolerogenic by the immune system. The former is made …

Oncolytic viruses (OVs) are an emerging treatment option for many cancer types and have
recently been the focus of extensive research aiming to develop their therapeutic potential …

Viruses elicit cell and organismic stress, and offset homeostasis. They trigger intrinsic, innate
and adaptive immune responses, which limit infection. Viruses restore homeostasis by …