Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …

BACKGROUND: Nearly all membrane and secreted proteins, as well as numerous
intracellular proteins are glycosylated. However, contrary to proteins which are defined by …

The detailed examination of enzyme molecules by mass spectrometry and other techniques
continues to identify hundreds of distinct PTMs. Recently, global analyses of enzymes using …

Cancer immunotherapy is revolutionizing oncology and has emerged as a promising
strategy for the treatment of multiple cancers. Indoleamine 2, 3-dioxygenase 1 (IDO1), an …

The non‐classical function of acetylcholine (ACh) has been reported in neuroinflammation
that represents the modulating factor in immune responses via activation of α7 nicotinic …

Acetylcholine (ACh) regulates inflammation via α7 nicotinic acetylcholine receptor (α7
nAChR). Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune …

Genistein, 4′, 5, 7-trihydroxyisoflavone, is a major isoflavone in soybean, which is known
as phytestrogen having known benefit to brain functions. Being a common phytestrogen, the …

Carbohydrates fulfil many common as well as extremely important functions in nature. They
show a variety of molecular displays–eg, free mono-, oligo-, and polysaccharides …

AChE enzymatic inhibition is a core focus of pharmacological intervention in A lzheimer's
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …

High-throughput, quantitative processing of N-linked glycans would facilitate large-scale
studies correlating the glycome with disease and open the field to basic and applied …