Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level
Protein arginine methyltransferases (PRMTs) catalyze the methyl transfer to the arginine
residues of protein substrates and are classified into three major types based on the final …
residues of protein substrates and are classified into three major types based on the final …
[HTML][HTML] Protein arginine methyltransferase 3: A crucial regulator in metabolic reprogramming and gene expression in cancers
SH Hsu, WC Hung - Cancer letters, 2023 - Elsevier
Post-translational modification (PTM) of proteins increases proteome diversity, which is
critical for maintaining cellular homeostasis. The importance of protein methylation in the …
critical for maintaining cellular homeostasis. The importance of protein methylation in the …
Allosteric modulator discovery: from serendipity to structure-based design
Allosteric modulators bound to structurally diverse allosteric sites can achieve better
pharmacological advantages than orthosteric ligands. The discovery of allosteric …
pharmacological advantages than orthosteric ligands. The discovery of allosteric …
Identification and inhibition of the druggable allosteric site of SARS-CoV-2 NSP10/NSP16 methyltransferase through computational approaches
Since its emergence in early 2019, the respiratory infectious virus, SARS-CoV-2, has
ravaged the health of millions of people globally and has affected almost every sphere of …
ravaged the health of millions of people globally and has affected almost every sphere of …
Allosteric modulation of protein arginine methyltransferase 5 (PRMT5)
RL Palte, SE Schneider, MD Altman… - ACS Medicinal …, 2020 - ACS Publications
Protein arginine methyltransferase 5 (PRMT5) belongs to a family of enzymes that regulate
the posttranslational modification of histones and other proteins via methylation of arginine …
the posttranslational modification of histones and other proteins via methylation of arginine …
Non-histone arginine methylation by protein arginine methyltransferases
Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing,
DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent …
DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent …
Targeting epigenetic regulation for cancer therapy using small molecule inhibitors
A Kumar, L Emdad, PB Fisher, SK Das - Advances in Cancer Research, 2023 - Elsevier
Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …
posttranslational modification, chromatin composition or organization and regulatory …
Methyltransferase inhibitors: competing with, or exploiting the bound cofactor
R Ferreira de Freitas, D Ivanochko, M Schapira - Molecules, 2019 - mdpi.com
Protein methyltransferases (PMTs) are enzymes involved in epigenetic mechanisms, DNA
repair, and other cellular machineries critical to cellular identity and function, and are an …
repair, and other cellular machineries critical to cellular identity and function, and are an …
Discovery of a first-in-class protein arginine methyltransferase 6 (PRMT6) covalent inhibitor
Y Shen, F Li, MM Szewczyk, L Halabelian… - Journal of medicinal …, 2020 - ACS Publications
Protein arginine methyltransferase 6 (PRMT6) plays important roles in several biological
processes associated with multiple cancers. Well-characterized potent, selective, and cell …
processes associated with multiple cancers. Well-characterized potent, selective, and cell …
The methylation status of the epigenome: its emerging role in the regulation of tumor angiogenesis and tumor growth, and potential for drug targeting
L Pirola, O Ciesielski, A Balcerczyk - Cancers, 2018 - mdpi.com
Approximately 50 years ago, Judah Folkman raised the concept of inhibiting tumor
angiogenesis for treating solid tumors. The development of anti-angiogenic drugs would …
angiogenesis for treating solid tumors. The development of anti-angiogenic drugs would …