Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …

The immune system plays critical roles in both autoimmunity and cancer, diseases at
opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance …

Dendritic cells (DCs) are crucial mediators of innate and adaptive antitumor immunity,
whereas exogenously and endogenously driven lipid accumulation causes immune …

T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been
a trending topic in recent years due to its differential expression in a wide range of …

Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in
pancreatic cancer (PC) progression. However, driver genes that direct EV function, the EV …

In contrast to conventional dendritic cells (cDCs) that are constantly exposed to microbial
signals at anatomical barriers, cDCs in systemic lymphoid organs are sheltered from …

The tumor microenvironment (TME) is a complex system characterized by low oxygen, low
pH, high pressure, and numerous growth factors and protein hydrolases that regulate a wide …

Lung cancer (LC) and tuberculosis (TB) are two major global public health problems, and
the incidence of LC-TB is currently on the rise. Therefore effective clinical interventions are …

Numerous preclinical studies have demonstrated the inhibitory function of T cell
immunoglobulin mucin domain-containing protein 3 (Tim-3) on T cells as an inhibitory …

Glucocorticoids are steroid hormones that regulate a host of cellular and physiological
functions. However, they are arguably best known for their potent anti-inflammatory …