Mathematical modeling of protein misfolding mechanisms in neurological diseases: a historical overview

F Carbonell, Y Iturria-Medina, AC Evans - Frontiers in Neurology, 2018 - frontiersin.org
Protein misfolding refers to a process where proteins become structurally abnormal and lose
their specific 3-dimensional spatial configuration. The histopathological presence of …

Eigenelements of a general aggregation-fragmentation model

M Doumic Jauffret, P Gabriel - Mathematical Models and Methods in …, 2010 - World Scientific
We consider a linear integro-differential equation which arises to describe both aggregation-
fragmentation processes and cell division. We prove the existence of a solution (λ,, ϕ) to the …

A non‐conservative Harris ergodic theorem

V Bansaye, B Cloez, P Gabriel… - Journal of the London …, 2022 - Wiley Online Library
We consider non‐conservative positive semigroups and obtain necessary and sufficient
conditions for uniform exponential contraction in weighted total variation norm. This ensures …

Statistical estimation of a growth-fragmentation model observed on a genealogical tree

M Doumic, M Hoffmann, N Krell, L Robert - 2015 - projecteuclid.org
We raise the issue of estimating the division rate for a growing and dividing population
modelled by a piecewise deterministic Markov branching tree. Such models have broad …

A mathematical analysis of the dynamics of prion proliferation

ML Greer, L Pujo-Menjouet, GF Webb - Journal of theoretical biology, 2006 - Elsevier
How do the normal prion protein (PrPC) and infectious prion protein (PrPSc) populations
interact in an infected host? To answer this question, we analyse the behavior of the two …

Prion dynamics and the quest for the genetic determinant in protein-only inheritance

SS Sindi, TR Serio - Current opinion in microbiology, 2009 - Elsevier
According to the prion hypothesis, proteins may act in atypical roles as genetic elements of
infectivity and inheritance by undergoing self-replicating changes in physical state. While the …

Spectral gap for the growth-fragmentation equation via Harris's Theorem

JA Cañizo, P Gabriel, H Yoldas - SIAM Journal on Mathematical Analysis, 2021 - SIAM
We study the long-time behavior of the growth-fragmentation equation, a nonlocal linear
evolution equation describing a wide range of phenomena in structured population …

Asymptotic behaviour of neuron population models structured by elapsed-time

JA Cañizo, H Yoldaş - Nonlinearity, 2019 - iopscience.iop.org
We study two population models describing the dynamics of interacting neurons, initially
proposed by Pakdaman et al (2010 Nonlinearity 23 55–75) and Pakdaman et al (2014 J …

Estimating the rate of prion aggregate amplification in yeast with a generation and structured population model

HT Banks, KB Flores, CR Langlois… - Inverse Problems in …, 2018 - Taylor & Francis
Prions are a special class of proteins capable of adopting multiple (misfolded)
conformations, some of which have been associated with fatal diseases in mammals such …

[PDF][PDF] Analysis of a model for the dynamics of prions

J Pruss, L Pujo-Menjouet, GF Webb… - … SYSTEMS SERIES B, 2006 - math.univ-lyon1.fr
A mathematical model for the dynamics of prion proliferation is analyzed. The model
involves a system of three ordinary differential equations for the normal prion forms, the …