[HTML][HTML] Next generation protein structure predictions and genetic variant interpretation
The need to make sense of the thousands of genetic variants uncovered every day in terms
of pathology or biological mechanism is acute. Many insights into how genetic changes …
of pathology or biological mechanism is acute. Many insights into how genetic changes …
Overview of methods for characterization and visualization of a protein–protein interaction network in a multi-omics integration context
V Robin, A Bodein, MP Scott-Boyer… - Frontiers in Molecular …, 2022 - frontiersin.org
At the heart of the cellular machinery through the regulation of cellular functions, protein–
protein interactions (PPIs) have a significant role. PPIs can be analyzed with network …
protein interactions (PPIs) have a significant role. PPIs can be analyzed with network …
EXPANSION: a webserver to explore the functional consequences of protein-coding alternative splice variants in cancer genomics
Abstract Summary EXPANSION (https://expansion. bioinfolab. sns. it/) is an integrated web-
server to explore the functional consequences of protein-coding alternative splice variants …
server to explore the functional consequences of protein-coding alternative splice variants …
PROTEORIZER: A holistic approach to untangle functional consequences of variants of unknown significance.
Most in silico tools only use data closely related to the gene-of-interest or initial research
question. This gene-focused research is prone to ignoring low-count and rare variants in the …
question. This gene-focused research is prone to ignoring low-count and rare variants in the …
Developing targeted therapies for pediatric PFA ependymoma
AL Jenseit - 2024 - archiv.ub.uni-heidelberg.de
PFA ependymomas are highly aggressive brain tumors typically arising in young children
(median age 3 years) and characterized by a poor outcome (10-year OS< 60%). Standard of …
(median age 3 years) and characterized by a poor outcome (10-year OS< 60%). Standard of …
Assessing functional impact of amino acid alterations in proteins
JC Gonzalez Sanchez - 2022 - archiv.ub.uni-heidelberg.de
Genome sequencing efforts, coupled with technological advances and cost reductions, have
led to the discovery of an increasing number of disease-related genetic variants. For the vast …
led to the discovery of an increasing number of disease-related genetic variants. For the vast …