Studies of bioactive lipids in general and sphingolipids in particular have intensified over the
past several years, revealing an unprecedented and unanticipated complexity of the …

The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as
a critical regulator of many physiological and pathophysiological processes, including …

The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …

Previously, a synbiotic combination of probiotic Lactobacillus gasseri 505 (LG) and a new
prebiotic, Cudrania tricuspidata leaf extract (CT) in fermented milk, designated FCT, showed …

Background: Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are anti-
inflammatory but have been linked in some studies to Crohn disease (CD) and ulcerative …

Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit
various immune cells to the site of inflammation and activates the production of mediators to …

Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Purpose: Sphingosine kinases (SK1 and SK2) regulate tumor growth by generating the
mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). This phase I study …

The bioactive sphingolipids ceramide, sphingosine and sphingosine‐1‐phosphate (S1P)
are important signalling molecules that regulate a diverse array of cellular processes. Most …

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from
proliferation to cell death. Sphingolipids are modified in multiple cancers and are …