Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Recent advances in the field of genomics have largely been due to the ability to sequence
DNA at increasing throughput and decreasing cost. DNA sequencing was first introduced in …

The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …

Motivation: Next-generation sequencing technologies generate millions of short sequence
reads, which are usually aligned to a reference genome. In many applications, the key …

In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation
data, providing a user-friendly analysis workflow that yields detailed hypertext reports …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Background Whole-genome bisulfite sequencing (WGBS) is becoming an increasingly
accessible technique, used widely for both fundamental and disease-oriented research …

A combination of bisulfite treatment of DNA and high-throughput sequencing (BS-Seq) can
capture a snapshot of a cell's epigenomic state by revealing its genome-wide cytosine …