Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

Bone is a richly vascularized connective tissue. As the main source of oxygen, nutrients,
hormones, neurotransmitters and growth factors delivered to the bone cells, vasculature is …

Bone regeneration is a complex process requiring highly orchestrated interactions between
different cells and signals to form new mineralized tissue. Blood vessels serve as a structural …

The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells,
osteoprogenitors and osteoblasts sustaining lifelong bone formation. Osteogenesis is …

In addition to their conventional role as a conduit system for gases, nutrients, waste products
or cells, blood vessels in the skeletal system play active roles in controlling multiple aspects …

While blood vessels play important roles in bone homeostasis and repair, fundamental
aspects of vascular function in the skeletal system remain poorly understood. Here we show …

Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

Bone resorption by osteoclasts and bone formation by osteoblasts are tightly coupled
processes implicating factors in TNF, bone morphogenetic protein, and Wnt families. In …

The importance of the vascular supply for bone is well-known to orthopaedists but is still
rather overlooked within the wider field of skeletal research. Blood supplies oxygen …