The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

The ability to maintain a functional proteome, or proteostasis, declines during the ageing
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …

Protein accumulation and aggregation with a concomitant loss of proteostasis often
contribute to neurodegenerative diseases, and the ubiquitin–proteasome system plays a …

The ubiquitin-proteasome system (UPS) has been implicated in neurodegenerative
diseases based on the presence of deposits consisting of ubiquitylated proteins in affected …

The ubiquitin proteasome system maintains protein homeostasis by regulating the
breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The …

Damaged and misfolded proteins accumulate during the aging process, impairing cell
function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) …

The precise degradation of dysfunctional mitochondria by mitophagy is essential for
maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

Intracellular accumulation of altered and misfolded proteins is the basis of most
neurodegenerative disorders. Altered proteins are usually organised in the form of toxic …