Methods and compositions for nucleic acid analysis

S Saxonov - US Patent 9,347,059, 2016 - Google Patents
Provided herein are methods, compositions, and kits for assays, many of which involve
amplification reactions such as digital PCR or droplet digital PCR. The assays may be used …

Droplet-based assay system

BW Colston, BJ Hindson, KD Ness… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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Droplet generation for droplet-based assays

KD Ness, CF Kelly, DA Masquelier - US Patent 9,500,664, 2016 - Google Patents
A system, including method and apparatus, for generating droplets suitable for droplet-
based assays. The disclosed systems may include either one-piece or multi-piece droplet …

Method of mixing fluids by coalescence of multiple emulsions

BJ Hindson, BW Colston Jr, KD Ness… - US Patent …, 2015 - Google Patents
US9194861B2 - Method of mixing fluids by coalescence of multiple emulsions - Google Patents
US9194861B2 - Method of mixing fluids by coalescence of multiple emulsions - Google Patents …

Bead-Based Multiplexed Analytical Methods and Instrumentation

A Shenderov, R Kouri, V Grichko - US Patent App. 12/596,897, 2010 - Google Patents
BACKGROUND 0002 Droplet microactuators are used to conduct a wide variety of droplet
operations. A droplet microactuator typi cally includes two Substrates separated by a space …

System for forming an array of emulsions

KD Ness, BJ Hindson, BW Colston Jr… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation https://patents. darts-ip. com/? family=
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System for forming an array of emulsions

BJ Hindson, KD Ness, BW Colston… - US Patent …, 2015 - Google Patents
Abstract System, including apparatus and methods, for forming an array of emulsions. The
system may comprise a plate including an array of emulsion production units. Each unit may …

Apparatuses and methods for manipulating droplets on a printed circuit board

VK Pamula, MG Pollack, RB Fair - US Patent 8,349,276, 2013 - Google Patents
Apparatuses and methods for manipulating droplets on a printed circuit board (PCB) are
disclosed. Droplets are actu ated upon a printed circuit board substrate surface by the …

System for hot-start amplification via a multiple emulsion

BJ Hindson - US Patent 8,709,762, 2014 - Google Patents
Abstract System, including methods, apparatus, compositions, and kits, for making and using
compound droplets of a multiple emulsion to supply an amplification reagent, such as a heat …

System for droplet-based assays using an array of emulsions

BJ Hindson, KD Ness, BW Colston… - US Patent …, 2016 - Google Patents
Abstract System, including method and apparatus, for performing droplet-based assays. In
the method, an emulsion may be obtained that includes droplets packed closely together in …