Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

AMPK is an important kinase regulating energy homeostasis and also a key protein involved
in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular …

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

Abstract α-Synuclein misfolds into pathological forms that lead to various neurodegenerative
diseases known collectively as α-synucleinopathies. In this Review, we provide a …

The increasing prevalence of Parkinson disease (PD) highlights the need to develop
interventions aimed at slowing or halting its progression. As a result of sophisticated disease …

Synuclein aggregation in neuronal cells is the primary underlying cause of
synucleinopathies. Changes in gene expression patterns, structural modifications, and …

Differentiated status, low regenerative capacity and complex signaling make neuronal
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,
where proteins, lipids, and organelles are degraded and recycled. According to the way the …

Alterations in mitochondrial function and morphology are associated with many human
diseases, including cancer and neurodegenerative diseases. Mitochondrial impairment is …

High-mobility group box-1 (HMGB1) is a nuclear protein associated with early inflammatory
changes upon extracellular secretion expressed in various cells, including neurons and …