Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms

S Cankat, MU Demael, L Swadling - Cellular & molecular immunology, 2024 - nature.com
Members of the coronaviridae family are endemic to human populations and have caused
several epidemics and pandemics in recent history. In this review, we will discuss the …

SARS-CoV-2 JN. 1 variant evasion of IGHV3-53/3-66 B cell germlines

I Paciello, G Maccari, G Pierleoni, F Perrone… - Science …, 2024 - science.org
The severe acute respiratory syndrome coronavirus 2 variant JN. 1 recently emerged as the
dominant variant despite having only one amino acid change on the spike (S) protein …

Protective neutralizing epitopes in SARS‐CoV‐2

H Liu, IA Wilson - Immunological reviews, 2022 - Wiley Online Library
The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …

High-resolution map of the Fc functions mediated by COVID-19-neutralizing antibodies

I Paciello, G Maccari, E Pantano… - Proceedings of the …, 2024 - National Acad Sciences
A growing body of evidence shows that fragment crystallizable (Fc)-dependent antibody
effector functions play an important role in protection from severe acute respiratory …

Anatomy of Omicron BA. 1 and BA. 2 neutralizing antibodies in COVID-19 mRNA vaccinees

E Andreano, I Paciello, S Marchese, L Donnici… - Nature …, 2022 - nature.com
Abstract SARS-CoV-2 vaccines, administered to billions of people worldwide, mitigate the
effects of the COVID-19 pandemic, however little is known about the molecular basis of …

Monoclonal antibodies specific for SARS-CoV-2 spike protein suitable for multiple applications for current variants of concern

MS Morgan, K Yan, TT Le, RA Johnston, AA Amarilla… - Viruses, 2022 - mdpi.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has spawned an ongoing demand for …

Antigenic sin and multiple breakthrough infections drive converging evolution of COVID-19 neutralizing responses

I Paciello, G Pierleoni, E Pantano, G Antonelli, P Pileri… - Cell Reports, 2024 - cell.com
Understanding the evolution of the B cell response to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants is fundamental to design the next generation of …

mRNA vaccines and hybrid immunity use different B cell germlines against Omicron BA. 4 and BA. 5

E Andreano, I Paciello, G Pierleoni, G Maccari… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome 2 Omicron BA. 4 and BA. 5 are characterized by high
transmissibility and ability to escape natural and vaccine induced immunity. Here we test the …

SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

A Onnis, E Andreano, C Cassioli, F Finetti… - Journal of Experimental …, 2022 - rupress.org
CTL-mediated killing of virally infected or malignant cells is orchestrated at the immune
synapse (IS). We hypothesized that SARS-CoV-2 may target lytic IS assembly to escape …