R/qtl2: software for mapping quantitative trait loci with high-dimensional data and multiparent populations
R/qtl2 is an interactive software environment for mapping quantitative trait loci (QTL) in
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities
Characterizing population variability, including identifying susceptible populations and
quantifying their increased susceptibility, is an important aspect of chemical risk assessment …
quantifying their increased susceptibility, is an important aspect of chemical risk assessment …
[HTML][HTML] Giving the genes a shuffle: using natural variation to understand host genetic contributions to viral infections
SR Leist, RS Baric - Trends in Genetics, 2018 - cell.com
The laboratory mouse has proved an invaluable model to identify host factors that regulate
the progression and outcome of virus-induced disease. The paradigm is to use single-gene …
the progression and outcome of virus-induced disease. The paradigm is to use single-gene …
Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice
Host genetic variation is known to contribute to differential pathogenesis following infection.
Mouse models allow direct assessment of host genetic factors responsible for susceptibility …
Mouse models allow direct assessment of host genetic factors responsible for susceptibility …
Male infertility is responsible for nearly half of the extinction observed in the mouse collaborative cross
The goal of the Collaborative Cross (CC) project was to generate and distribute over 1000
independent mouse recombinant inbred strains derived from eight inbred founders. With …
independent mouse recombinant inbred strains derived from eight inbred founders. With …
Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation
Gene transcription profiles across tissues are largely defined by the activity of regulatory
elements, most of which correspond to regions of accessible chromatin. Regulatory element …
elements, most of which correspond to regions of accessible chromatin. Regulatory element …
Whole genome sequencing and progress toward full inbreeding of the mouse collaborative cross population
Two key features of recombinant inbred panels are well-characterized genomes and
reproducibility. Here we report on the sequenced genomes of six additional Collaborative …
reproducibility. Here we report on the sequenced genomes of six additional Collaborative …
Oas1b-dependent immune transcriptional profiles of West Nile virus infection in the collaborative cross
R Green, C Wilkins, S Thomas, A Sekine… - G3: Genes …, 2017 - academic.oup.com
The oligoadenylate-synthetase (Oas) gene locus provides innate immune resistance to virus
infection. In mouse models, variation in the Oas1b gene influences host susceptibility to …
infection. In mouse models, variation in the Oas1b gene influences host susceptibility to …
A locus on chromosome 15 contributes to acute ozone-induced lung injury in collaborative cross mice
Ozone (O3)-induced respiratory toxicity varies considerably within the human population
and across inbred mouse strains, indicative of gene-environment interactions (GxE). Though …
and across inbred mouse strains, indicative of gene-environment interactions (GxE). Though …