Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Periodontitis is a bacterial infectious disease, and many inflammatory cytokines regulate
periodontitis pathophysiology through a crosstalk between tissue cells and immune cells …

In the past few years, new developments have been reported on the role of Toll-like
receptors (TLRs) in chronic inflammation in rheumatic diseases. The inhibitory function of …

Innate immune signaling plays an important role in inflammation, and dysregulation of
signaling components within this pathway has been focused as a critical mediator in …

Most members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) families
transduce signals via a canonical pathway involving the MyD88 adapter and the interleukin …

Background and Aims: Activation of the inflammasome NLRP3 (NOD-, LRR-and pyrin
domain containing 3) contributes to the development of non-alcoholic fatty liver disease …

Increasing evidence supports vanillin and its analogs as potent toll-like receptor signaling
inhibitors that strongly attenuate inflammation, though, the underlying molecular mechanism …