Management of opioid analgesic overdose
EW Boyer - New England Journal of Medicine, 2012 - Mass Medical Soc
Management of Opioid Analgesic Overdose | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …
content The New England Journal of Medicine homepage Advanced Search SEARCH …
A review of acetaminophen poisoning
MJ Hodgman, AR Garrard - Critical care clinics, 2012 - criticalcare.theclinics.com
Acetaminophen (APAP) is a safe and effective analgesic and antipyretic. 1 It is widely
available as a single-component medication and also as a component of a plethora of …
available as a single-component medication and also as a component of a plethora of …
What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?
RG Hendrickson - Clinical Toxicology, 2019 - Taylor & Francis
While the traditional intravenous N-acetylcysteine (NAC) dosing regimen works well for the
vast majority of acetaminophen overdoses, there may be cases of massive overdose where …
vast majority of acetaminophen overdoses, there may be cases of massive overdose where …
Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2)
AL Chiew, GK Isbister, KA Kirby, CB Page… - Clinical …, 2017 - Taylor & Francis
Context: Paracetamol is commonly taken in overdose, with increasing concerns that those
taking “massive” overdoses have higher rates of hepatotoxicity and may require higher …
taking “massive” overdoses have higher rates of hepatotoxicity and may require higher …
Outcomes from massive paracetamol overdose: a retrospective observational study
DJB Marks, PI Dargan, JRH Archer… - British journal of …, 2017 - Wiley Online Library
LINKED ARTICLE This article is commented on by Bateman DN and Dear JW. Should we
treat very large paracetamol overdose differently? Br J Clin Pharmacol 2017; 83: 1163–5 …
treat very large paracetamol overdose differently? Br J Clin Pharmacol 2017; 83: 1163–5 …
Acetaminophen induces apoptosis in rat cortical neurons
Background Acetaminophen (AAP) is widely prescribed for treatment of mild pain and fever
in western countries. It is generally considered a safe drug and the most frequently reported …
in western countries. It is generally considered a safe drug and the most frequently reported …
Evidence for the changing regimens of acetylcysteine
Paracetamol overdose prior to the introduction of acetylcysteine was associated with
significant morbidity. Acetylcysteine is now the mainstay of treatment for paracetamol …
significant morbidity. Acetylcysteine is now the mainstay of treatment for paracetamol …
Hepatotoxicity Despite Early Administration of Intravenous N‐Acetylcysteine for Acute Acetaminophen Overdose
S Doyon, W Klein‐Schwartz - Academic Emergency Medicine, 2009 - Wiley Online Library
Objectives: The objective was to evaluate the effectiveness of intravenous N‐acetylcysteine
(IV NAC; 300 mg/kg over 21 hours) in early acute acetaminophen (APAP) overdose patients …
(IV NAC; 300 mg/kg over 21 hours) in early acute acetaminophen (APAP) overdose patients …
When do the aminotransferases rise after acute acetaminophen overdose?
TJ Green, MLA Sivilotti, C Langmann, M Yarema… - Clinical …, 2010 - Taylor & Francis
Context. Rising aminotransferases (ATs)[either aspartate aminotransferase (AST) or alanine
aminotransferase (ALT) are one of the first signs of hepatotoxicity following acetaminophen …
aminotransferase (ALT) are one of the first signs of hepatotoxicity following acetaminophen …
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver
M Hadi, S Dragovic, R van Swelm, B Herpers… - Archives of …, 2013 - Springer
Abstract N-acetyl-meta-aminophenol (AMAP) is generally considered as a non-toxic
regioisomer of the well-known hepatotoxicant acetaminophen (APAP). However, so far …
regioisomer of the well-known hepatotoxicant acetaminophen (APAP). However, so far …