The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
MS Nielsen, CJM van Opbergen… - Physiological …, 2023 - journals.physiology.org
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …
mechanical and electrical junctions. Although described in some detail by light microscopy …
Adhesion protein structure, molecular affinities, and principles of cell-cell recognition
The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …
they" recognize" one another with high specificity. We discuss recent progress in …
Structure, function, and regulation of desmosomes
AP Kowalczyk, KJ Green - Progress in molecular biology and translational …, 2013 - Elsevier
Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells
by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate …
by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate …
Structural biology in situ—the potential of subtomogram averaging
JAG Briggs - Current opinion in structural biology, 2013 - Elsevier
Cryo-electron tomography provides low-resolution 3D views of cells, organelles, or viruses.
Macromolecular complexes present in multiple copies can be subsequently identified within …
Macromolecular complexes present in multiple copies can be subsequently identified within …
Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy
Aims Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary heart muscle
disorder associated with sudden cardiac death. Its pathophysiology is still poorly …
disorder associated with sudden cardiac death. Its pathophysiology is still poorly …
The desmosome comes into focus
The desmosome is a cell–cell adhesive junction that provides integrity and mechanical
resistance to tissues through its attachment to the intermediate filament cytoskeleton …
resistance to tissues through its attachment to the intermediate filament cytoskeleton …
Protein modeling: what happened to the “protein structure gap”?
T Schwede - Structure, 2013 - cell.com
Computational modeling of three-dimensional macromolecular structures and complexes
from their sequence has been a long-standing vision in structural biology. Over the last 2 …
from their sequence has been a long-standing vision in structural biology. Over the last 2 …
Autoantibody-specific signalling in pemphigus
Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and
mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein …
mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein …
A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms
J Mahamid, R Schampers, H Persoon… - Journal of structural …, 2015 - Elsevier
Cryo-electron tomography provides 3D views of cellular architecture with molecular
resolution. A principal limitation of cryo-transmission electron microscopy performed on cells …
resolution. A principal limitation of cryo-transmission electron microscopy performed on cells …
Higher-order architecture of rhodopsin in intact photoreceptors and its implication for phototransduction kinetics
The visual pigment rhodopsin belongs to the family of G protein-coupled receptors that can
form higher oligomers. It is controversial whether rhodopsin forms oligomers and whether …
form higher oligomers. It is controversial whether rhodopsin forms oligomers and whether …