Abstract Purpose of Review Recent developments in regenerative medicine have
precipitated the need to expand gene-modified human T cells to numbers that exceed the …

Background The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use
needs to be cost effective, safe and scaled up. Current methods of expansion on tissue …

Increasing success of adaptive cell therapy (ACT), such as genetically engineered T cells to
express chimeric antigen receptors (CARs) proven to be highly significant technological …

The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most
widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion …

Background aims The need for large-scale production of mesenchymal stromal cell (MSC)-
based cellular therapeutics continues to grow around the globe. Manual cell expansion …

Establishing a master cell bank requires compliance with the federal regulations. These
regulations work to ensure the quality, safety, and efficacy of the finished product …

BACKGROUND [0003] Regenerative medicine, applied in the form of stem cell therapy,
offers the possibility of treating many previ ously incurable diseases. Numerous types of …