New developments in prokinetic therapy for gastric motility disorders

M Camilleri, J Atieh - Frontiers in pharmacology, 2021 - frontiersin.org
Prokinetic agents amplify and coordinate the gastrointestinal muscular contractions to
facilitate the transit of intra-luminal content. Following the institution of dietary …

Prokinetics in gastroparesis

A Acosta, M Camilleri - Gastroenterology Clinics, 2015 - gastro.theclinics.com
Gastroparesis is defined as objectively delayed gastric emptying in the absence of
mechanical obstruction and in the presence of upper gastrointestinal symptoms including …

Pathophysiology and treatment of gastrointestinal motility disorders in the acutely ill

AM Deane, MJ Chapman… - Nutrition in Clinical …, 2019 - Wiley Online Library
Gastrointestinal dysmotility causes delayed gastric emptying, enteral feed intolerance, and
functional obstruction of the small and large intestine, the latter functional obstructions being …

Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives

JE Stevens, KL Jones, CK Rayner… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Gastroparesis is an important clinical disorder characterised by delayed gastric
emptying in the absence of mechanical outlet obstruction. Idiopathic, diabetes and …

Measurement of gastric emptying in the critically ill

P Kar, KL Jones, M Horowitz, MJ Chapman, AM Deane - Clinical nutrition, 2015 - Elsevier
Background & aims Enteral nutrition is important in critically ill patients and is usually
administered via a nasogastric tube. As gastric emptying is frequently delayed, and this …

Pharmacological treatments for gastroparesis

M Camilleri, KJ Jencks - Pharmacological Reviews, 2024 - Elsevier
Gastroparesis is a neurogastrointestinal disorder of motility in which patients experience
symptoms of nausea, vomiting, bloating, early satiety, postprandial fullness, upper …

Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement

MJ Chapman, LK Besanko, CM Burgstad, RJ Fraser… - Gut, 2011 - gut.bmj.com
Objective It is assumed that delayed gastric emptying (GE) occurs frequently in critical
illness; however, the prevalence of slow GE has not previously been assessed using …

Prokinetic drugs for feed intolerance in critical illness: current and potential therapies

AM Deane, RJ Fraser, MJ Chapman - Critical Care and Resuscitation, 2009 - Elsevier
Studies consistently show that nasogastric nutrition delivers only about 60% of nutritional
goals in critically ill patients. The predominant reason is abnormal gastric motility, leading to …

Should we stop prescribing metoclopramide as a prokinetic drug in critically ill patients?

YG van der Meer, WA Venhuizen, DK Heyland… - Critical Care, 2014 - Springer
Abstract Regulatory agencies in North America and Europe recently re-evaluated the safety
of metoclopramide. This re-evaluation resulted in recommendations and restrictions in order …

Emerging strategies for the treatment of gastroparesis

J Langworthy, HP Parkman, R Schey - Expert review of …, 2016 - Taylor & Francis
Gastroparesis is a syndrome of delayed gastric emptying in the absence of mechanical
obstruction. Symptoms can be debilitating, affect nutritional states, and significantly impact …