Long noncoding RNAs (lncRNAs) have emerged as significant players in almost every level
of gene function and regulation. Thus, characterizing the structures and interactions of …

RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …

The discovery of drivers of cancer has traditionally focused on protein-coding genes,,–. Here
we present analyses of driver point mutations and structural variants in non-coding regions …

Synonymous mutations have been viewed as silent mutations, since they only affect the
DNA and mRNA, but not the amino acid sequence of the resulting protein. Nonetheless …

Long non-coding RNAs (lncRNAs) are emerging as important regulators in different
biological processes through various ways. Because the related data, especially mutations …

Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the
major challenges of cancer research. This challenge is more acute and far from solved for …

The SARS-CoV-2 virus is a recently-emerged zoonotic pathogen already well adapted to
transmission and replication in humans. Although the mutation rate is limited, recently …

Genome‐wide association studies (GWAS) and whole‐exome sequencing (WES) generate
massive amounts of genomic variant information, and a major challenge is to identify which …

Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold
missing drivers of tumourigenesis, but few such “driver lncRNAs” are known. Until now, they …

Somatic mutations in the nuclear genome are required for tumor formation, but the functional
consequences of somatic mitochondrial DNA (mtDNA) mutations are less understood. Here …