Throughout the nervous system, moment-to-moment communication relies on postsynaptic
receptors to detect neurotransmitters and change the membrane potential. For the Cys-loop …

New hypotheses and predictions have arisen from recent work revealing atomic-scale or
near-atomic-scale structures of receptors in the 'Cys-loop'superfamily. How general is the …

We present a refined model of the membrane-associated Torpedo acetylcholine (ACh)
receptor at 4Å resolution. An improved experimental density map was obtained from 342 …

The discovery of artemisinin more than 30 years ago provided a completely new antimalarial
structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1 …

Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a
broad spectrum of ion channels and receptors. The subgroup α-Ctx specifically and …

Neurotransmitter receptors from the Cys-loop superfamily couple the binding of agonist to
the opening of an intrinsic ion pore in the final step in rapid synaptic transmission. Although …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

GABAA receptors are chloride ion channels that mediate fast synaptic transmission and
belong to a superfamily of pentameric ligand-gated ion channels. The recently published …

The growing interest in nicotinic receptors, because of their wide expression in neuronal and
non‐neuronal tissues and their involvement in several important CNS pathologies, has …

The ligand binding domain (LBD) of the nicotinic acetylcholine receptor has served as a
prototype for understanding molecular recognition in the family of neurotransmitter‐gated …