Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

G Keijzers, D Bakula, MA Petr, NGK Madsen… - International journal of …, 2018 - mdpi.com
Human exonuclease 1 (EXO1), a 5′→ 3′ exonuclease, contributes to the regulation of the
cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair …

A novel signature predicts prognosis and immunotherapy in lung adenocarcinoma based on cancer-associated fibroblasts

Q Ren, P Zhang, H Lin, Y Feng, H Chi… - Frontiers in …, 2023 - frontiersin.org
Background Extensive research has established the significant correlations between cancer-
associated fibroblasts (CAFs) and various stages of cancer development, including initiation …

DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

N Tomimatsu, B Mukherjee, JL Harris, FL Boffo… - Journal of Biological …, 2017 - ASBMB
End resection of DNA double-strand breaks (DSBs) to generate 3′-single-stranded DNA
facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair …

Investigating the importance of EGFR (− 216G/T), Exo1 (K589E) and LEP (− 2548G/A) gene polymorphisms with risk of lung cancer as potential diagnostic biomarker …

M Pezeshki, SM Hosseini, J Ansari… - Egyptian Journal of …, 2023 - Springer
Abstract Background In Iran, lung cancer is the third most common type of cancer and its
prevalence is increasing rapidly. Identification informative genetic polymorphisms in cancer …

Associations between Nine Polymorphisms in EXO1 and Cancer Susceptibility: A Systematic Review and Meta-Analysis of 39 Case-control Studies

M Zhang, D Zhao, C Yan, L Zhang, C Liang - Scientific reports, 2016 - nature.com
An increasing number of studies have highlighted the potential link between EXO1
polymorphisms and cancer risk, although no consensus has yet been obtained. Thus, we …

Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysis

J Chen, Z Wang, X Shen, X Cui… - Molecular Genetics & …, 2019 - Wiley Online Library
Background Colorectal cancer (CRC) is one of the most common malignant tumors. In the
present study, the expression profile of human multistage colorectal mucosa tissues …

EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients

Y Dai, Z Tang, Z Yang, L Zhang, Q Deng, X Zhang… - Cell Cycle, 2018 - Taylor & Francis
The roles of exonuclease 1 (EXO1) in hepatocellular carcinoma (HCC) tumorigenesis and
progression remain unclear. This study aimed to assess the prognostic value and …

Exonuclease 1 (EXO1) is a potential prognostic biomarker and correlates with immune infiltrates in lung adenocarcinoma

C Zhou, M Feng, X Chen, Y Gao, L Chen… - OncoTargets and …, 2021 - Taylor & Francis
Background Exonuclease 1 (EXO1) has been identified to be highly expressed in different
human malignancies, but its expression and prognostic role in lung adenocarcinoma …

Identifying general tumor and specific lung cancer biomarkers by transcriptomic analysis

BA Otálora-Otálora, DA Osuna-Garzón… - Biology, 2022 - mdpi.com
Simple Summary An adequate bioinformatic pipeline is a valuable tool for understanding
cancer mechanisms and identifying transcriptomic biomarkers of cancer and specific to lung …

[HTML][HTML] Polymorphisms in DNA mismatch repair pathway genes predict toxicity and response to cisplatin chemoradiation in head and neck squamous cell carcinoma …

GAS Nogueira, EFD Costa, L Lopes-Aguiar… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) is treated with cisplatin (CDDP) and
radiotherapy (RT), and distinct results are observed among patients with similar …