Purpose To review the impact of collaborative studies on advances in the biology and
treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods A …

Although somatically acquired genomic alterations have long been recognized as the
hallmarks of acute lymphoblastic leukemia (ALL), the last decade has shown that inherited …

Purpose Somatic deletions that affect the lymphoid transcription factor–coding gene IKZF1
have previously been reported as independently associated with a poor prognosis in …

The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …

Background Central nervous system tumours constitute 25% of all childhood cancers; more
than half are located in the posterior fossa and surgery is usually part of therapy. One of the …

Matrix metalloproteinases (MMPs) play a major role in extracellular matrix remodeling and
are involved in tumor cell invasion. Cancers such as childhood leukemia are characterized …

Pharmacogenomics is a fast-growing field of personalized medicine using a patient's
genomic profile to determine drug disposition or response to drug therapy, in order to …

Li W, Li X, Li X, et al. Onco Targets Ther. 2020; 13: 3129-3139. We, the Editors and
Publisher of OncoTargets and Therapy, have retracted the following article. Since …

Medulloblastoma (MB) is the most common pediatric malignant central nervous system
tumor. Overall survival in MB depends on treatment tuning. There is aneed for biomarkers of …

Background/Aim: Accumulated evidence has supported the notion that matrix
metalloproteinase (MMP) genotypes are associated with the susceptibility of many types of …