Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Cardiac hypertrophy, initially an adaptive response of the myocardium to stress, can
progress to heart failure. The epigenetic signature underlying this phenomenon is poorly …

Background Pathological cardiac hypertrophy is a major contributor of heart failure (HF),
which seriously threatens human's health world widely. Deregulation of m6A RNA …

The cardiovascular system is broadly composed of the heart, which pumps blood, and the
blood vessels, which carry blood to and from tissues of the body. Heart malformations are …

In patients with heart failure, reactivation of a fetal gene program, including atrial natriuretic
peptide (ANP) and brain natriuretic peptide (BNP), is a hallmark for maladaptive remodeling …

Wnt/β-catenin signaling is crucial for intestinal carcinogenesis and the maintenance of
intestinal cancer stem cells. Here we identify the histone methyltransferase Mll1 as a …

KMT2D, which encodes a histone H3K4 methyltransferase, has been implicated in human
congenital heart disease in the context of Kabuki syndrome. However, its role in heart …

The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor
(HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the …

There is a worldwide epidemic of cardiovascular diseases causing not only a public health
issue but also accounting for trillions of dollars of healthcare expenditure. Studies pertaining …