It has been estimated that up to one-third of the proteins encoded by the human genome
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …

The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions
by secreting multiple effectors with diverse biochemical activities. In particular, effectors of …

Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell
loss and diabetes mellitus. Here we report on five individuals from three different …

During homeostasis, the endoplasmic reticulum (ER) maintains productive transmembrane
and secretory protein folding that is vital for proper cellular function. The ER-resident HSP70 …

AMPylation is a biologically significant yet understudied post-translational modification
where an adenosine monophosphate (AMP) group is added to Tyrosine and Threonine …

The unfolded protein response (UPR) is a cellular stress response that is activated when
misfolded proteins accumulate in the endoplasmic reticulum (ER). Regulation of the UPR …

Background: In broiler chickens, the efficient utilization of macro-and micronutrients is
influenced by various metabolic pathways that are closely linked to feed efficiency (FE), a …

The reversal of ubiquitination induced by members of the SidE effector family of Legionella
pneumophila produces phosphoribosyl ubiquitin (PR-Ub) that is potentially detrimental to …

The AMP transferase, FICD, is an emerging drug target finetuning stress signaling in the
endoplasmic reticulum (ER). FICD is a bi-functional enzyme, catalyzing both AMP addition …

Cardiomyocytes require the HSP70 chaperone BiP to maintain proteostasis in the
endoplasmic reticulum (ER) following cardiac stress. The adenylyl transferase (AMPylase) …