The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

In consequence of their biological effects, conformationally constrained carbocyclic β-amino
acids have generated great interest among synthetic and medicinal chemists in the past 2 …

The lipases obtained from the genus Aspergillus present remarkable importance in
biotechnological applications, and numerous studies have reported the importance of the …

Many researchers have found fungi as a reliable source of lipase due to the versatility of
their properties, ease of mass production, thermal stability, pH stability, broad substrate …

Chiral nitrogenated compounds are highly attractive compounds because of their
importance in agrochemicals, fine chemicals, and pharmaceuticals but also due to their …

Peptide-based drug research has received high attention in the field of medicinal chemistry
over the past decade. For drug design, to improve proteolytic stability, it is desirable to …

Hydrolytic enzymes, such as lactamases or hydantoinases, can be valuably applied to
convert lactams (cyclic amides) and cyclic imides into optically pure compounds, for …

A convenient and robust stereocontrolled procedure has been developed for the synthesis
of novel trifluoromethyl-containing piperidine and azepane β-amino ester stereoisomers …

Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β-and γ-
amino acids through enzymatic ring cleavage of the corresponding lactams in organic …

The synthesis of some new functionalized azaheterocyclic β-amino esters with multiple
stereocenters has been achieved from readily available unsaturated bicyclic β-amino acids …