In CASP14, 39 research groups submitted more than 2500 3D models on 22 protein
complexes. In general, the community performed well in predicting the fold of the assemblies …

Symmetry in nature often emerges from self-assembly processes and serves a wide range of
functions. Cell surface layers (S-layers) form symmetrical lattices on many bacterial and …

Activating precursor B cell receptors of HIV-1 broadly neutralizing antibodies requires
specifically designed immunogens. Here, we compared the abilities of three such germline …

Assembly pathways of protein complexes should be precise and efficient to minimise
misfolding and unwanted interactions with other proteins in the cell. One way to achieve this …

Proteins are key components in many processes in living cells, and physical interactions
with other proteins and nucleic acids often form key parts of their functions. In many cases …

Symmetry in protein, and, more generally, in macromolecular assemblies is a key point to
understand their structure, stability and function. Many symmetrical assemblies are currently …

We present a new approach based on the Slope Chain Code to determine whether a curve
is rotational symmetrical and its order of symmetry. The proposed approach works for open …

The Tumor Necrosis Factor (TNF) and the TNF receptor (TNFR) superfamilies are composed
of 19 ligands and 30 receptors, respectively. The oligomeric properties of ligands, both …

In membrane proteins, symmetry and pseudosymmetry often have functional or evolutionary
implications. However, available symmetry detection methods have not been tested …

A comprehensive analysis of crystallographic data of 565 high-resolution protein
homodimers comprised of over 250,000 residues suggests that amino acids form two groups …