Obesity and associated insulin resistance predispose individuals to develop chronic
metabolic diseases, such as type 2 diabetes and cardiovascular disease. Although these …

Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

Regulatory T cells hold promise as targets for therapeutic intervention in autoimmunity, but
approaches capable of expanding antigen-specific regulatory T cells in vivo are currently not …

Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor
resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that …

Antigen-specific tolerance is a key goal of experimental immunotherapies for autoimmune
disease and allograft rejection. This outcome could selectively inhibit detrimental …

The gut microbiota contributes to the development of normal immunity but, when
dysregulated, can promote autoimmunity through various non-antigen-specific effects on …

Recent advances in immunotherapeutics have not yet changed the routine management of
autoimmune type 1 diabetes. There is an opportunity to repurpose therapeutics used to treat …

Type-1 diabetes in the nonobese diabetic (NOD) mouse starts with an insulitis stage,
wherein a mixed population of leukocytes invades the pancreas, followed by overt diabetes …

Recent advances in our understanding of the pathogenesis of type 1 diabetes have
occurred in all steps of the disease. This review outlines the pathogenic mechanisms utilized …

Type 1 diabetes in the nonobese diabetic mouse stems from an infiltration of the pancreatic
islets by a mixed population of immunocytes, which results in the impairment and eventual …