Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?

MZ Ratajczak, J Ratajczak - Leukemia, 2020 - nature.com
There are concepts in science that need time to overcome initial disbelief before finally
arriving at the moment when they are embraced by the research community. One of these …

Clinical utility of circulating non-coding RNAs—an update

S Anfossi, A Babayan, K Pantel, GA Calin - Nature reviews Clinical …, 2018 - nature.com
Over the past decade, the amount of research and the number of publications on
associations between circulating small and long non-coding RNAs (ncRNAs) and cancer …

Exosomes: from garbage bins to promising therapeutic targets

M H. Rashed, E Bayraktar, G K. Helal… - International journal of …, 2017 - mdpi.com
Intercellular communication via cell-released vesicles is a very important process for both
normal and tumor cells. Cell communication may involve exosomes, small vesicles of …

Extracellular vesicles: biology and emerging therapeutic opportunities

S El Andaloussi, I Mäger, XO Breakefield… - Nature reviews Drug …, 2013 - nature.com
Within the past decade, extracellular vesicles have emerged as important mediators of
intercellular communication, being involved in the transmission of biological signals …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

H Peinado, M Alečković, S Lavotshkin, I Matei… - Nature medicine, 2012 - nature.com
Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the
function of melanoma-derived exosomes in the formation of primary tumors and metastases …

Extracellular vesicles in renal disease

D Karpman, A Ståhl, I Arvidsson - Nature Reviews Nephrology, 2017 - nature.com
Extracellular vesicles, such as exosomes and microvesicles, are host cell-derived packages
of information that allow cell–cell communication and enable cells to rid themselves of …

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Y Lee, S El Andaloussi, MJA Wood - Human molecular genetics, 2012 - academic.oup.com
Exosomes and microvesicles are extracellular nanovesicles released by most but not all
cells. They are specifically equipped to mediate intercellular communication via the transfer …

[HTML][HTML] Exosomes/microvesicles as a mechanism of cell-to-cell communication

G Camussi, MC Deregibus, S Bruno, V Cantaluppi… - Kidney international, 2010 - Elsevier
Microvesicles (MVs) are circular fragments of membrane released from the endosomal
compartment as exosomes or shed from the surface membranes of most cell types. An …

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia–reperfusion-induced acute and chronic kidney injury

S Gatti, S Bruno, MC Deregibus, A Sordi… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse
acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation …