[HTML][HTML] Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural …

T Zhang, W Deng, Y Deng, Y Liu, S Xiao, Y Luo… - Biomedicine & …, 2023 - Elsevier
Acute myocardial infarction remains the leading cause of death in humans. Timely
restoration of blood perfusion to ischemic myocardium remains the most effective strategy in …

Thymoquinone: review of its potential in the treatment of neurological diseases

FH Pottoo, AM Ibrahim, A Alammar, R Alsinan, M Aleid… - Pharmaceuticals, 2022 - mdpi.com
Thymoquinone (TQ) possesses anticonvulsant, antianxiety, antidepressant, and
antipsychotic properties. It could be utilized to treat drug misuse or dependence, and those …

Natural essential oils as a new therapeutic tool in colorectal cancer

S Garzoli, P Alarcón-Zapata, G Seitimova… - Cancer Cell …, 2022 - Springer
Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the
second most common cause of cancer death (about 1 million per year). Historically, natural …

The role of thymoquinone in inflammatory response in chronic diseases

Y Liu, L Huang, MY Kim, JY Cho - International Journal of Molecular …, 2022 - mdpi.com
Anti-inflammatory therapies have been shown to be effective in the prevention of various
cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), the main …

Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature

M Imran, SA Khan, Abida, MK Alshammari, SM Alkhaldi… - Molecules, 2022 - mdpi.com
COVID-19 has had an impact on human quality of life and economics. Scientists have been
identifying remedies for its prevention and treatment from all possible sources, including …

Evaluation of conventional and hyaluronic acid-coated thymoquinone liposomes in an in vitro model of dry eye

E Landucci, C Mazzantini, M Calvani… - Pharmaceutics, 2023 - mdpi.com
Dry eye disease (DED) is a common ocular disorder characterized by an inadequate
lubrication of the eye by tears leading to inflammation and the alteration of the ocular …

Oleic acid-based vesicular nanocarriers for topical delivery of the natural drug thymoquinone: Improvement of anti-inflammatory activity

MC Bruno, A Gagliardi, A Mancuso, A Barone… - Journal of Controlled …, 2022 - Elsevier
The topical administration of a drug compound remains the first choice for the treatment of
many local skin ailments. Many skin diseases can be treated by applying the active …

Thymoquinone ameliorates carfilzomib-induced renal impairment by modulating oxidative stress markers, inflammatory/apoptotic mediators, and augmenting Nrf2 in …

MM Qadri, MF Alam, ZA Khired, RO Alaqi… - International Journal of …, 2023 - mdpi.com
Chemotherapy-induced kidney damage is an emerging problem that restricts cancer
treatment effectiveness. The proteasome inhibitor carfilzomib (CFZ) is primarily used to treat …

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

MH Sultan, S Javed, OA Madkhali, MI Alam… - Molecules, 2022 - mdpi.com
The present study aimed to develop a local dental nanoemulgel formulation of Nigella sativa
oil (NSO) for the treatment of periodontal diseases. NSO purchased from a local market was …

Experimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino …

A Khan, MA Alsahli, MA Aljasir… - Journal of …, 2023 - Taylor & Francis
Purpose Thymoquinone (TQ), a phytoconstituent of Nigella sativa seeds, has been studied
extensively in various cancer models. However, TQ's limited water solubility restricts its …