On the 400th anniversary of Harvey's Lumleian lectures, this review focuses on
“hemodynamic” forces associated with the movement of blood through arteries in humans …

Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular
events, dementia, and death. Decreased compliance of the central vasculature alters arterial …

Vascular endothelial function is essential for maintenance of health of the vessel wall and for
vasomotor control in both conduit and resistance vessels. These functions are due to the …

Physical activity has profound impacts on the vasculature in humans. Acute exercise
induces immediate changes in artery function, whereas repeated episodic bouts of exercise …

The effects of inactivity and exercise training on established and novel cardiovascular risk
factors are relatively modest and do not account for the impact of inactivity and exercise on …

Shear stress is an important stimulus to arterial adaptation in response to exercise and
training in humans. We recently observed significant reverse arterial flow and shear during …

The benefits of aerobic exercise (AE) training on blood pressure (BP) and arterial stiffness
are well established, but the effects of resistance training are less well delineated. The …

Changes in arterial shear stress induce functional and structural vasculature adaptations.
Recent studies indicate that substantial retrograde flow and shear can occur through human …

Current evidence indicates that the ability of physical activity to sustain a normal phenotype
of arterial endothelial cells (ECs) plays a central role in the beneficial effects of exercise (Ex) …

Endothelial adaptations to exercise training are not exclusively conferred within the active
muscle beds. Herein, we summarize key studies that have evaluated the impact of chronic …