Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder

N Eissa, M Al-Houqani, A Sadeq, SK Ojha… - Frontiers in …, 2018 - frontiersin.org
Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …

Unique roles of rare variants in the genetics of complex diseases in humans

Y Momozawa, K Mizukami - Journal of human genetics, 2021 - nature.com
Genome-wide association studies have identified> 10,000 genetic variants associated with
various phenotypes and diseases. Although the majority are common variants, rare variants …

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

YW Liu, MT Liong, YCE Chung, HY Huang, WS Peng… - Nutrients, 2019 - mdpi.com
This four-week, randomized, double-blind, placebo-controlled study investigated the effects
of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) …

Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits

DA Baribeau, E Anagnostou - Frontiers in neuroscience, 2015 - frontiersin.org
Oxytocin and vasopressin are pituitary neuropeptides that have been shown to affect social
processes in mammals. There is growing interest in these molecules and their receptors as …

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

GE DiCarlo, JI Aguilar, HJG Matthies… - The Journal of …, 2020 - Am Soc Clin Investig
The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT)
ensures the phasic nature of the DA signal, which underlies the ability of DA to encode …

Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database

J Li, T Cai, Y Jiang, H Chen, X He, C Chen, X Li… - Molecular …, 2016 - nature.com
Currently, many studies on neuropsychiatric disorders have utilized massive trio-based
whole-exome sequencing (WES) and whole-genome sequencing (WGS) to identify …

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies

R Wigton, J Radua, P Allen, B Averbeck… - Journal of Psychiatry and …, 2015 - jpn.ca
Background: Oxytocin (OXT) plays a prominent role in social cognition and may have clinical
applications for disorders such as autism, schizophrenia and social anxiety. The neural …

Neural circuits for social cognition: implications for autism

M Fernández, I Mollinedo-Gajate, O Peñagarikano - Neuroscience, 2018 - Elsevier
Social neuroscience, the study of the neurobiological basis of social behavior, has become
a major area of current research in behavioral neuroscience and psychiatry, since many …

Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder

S Nisar, M Haris - Molecular psychiatry, 2023 - nature.com
Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early
childhood and are characterized by qualitative abnormalities in social behaviors …

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

JA Coleman, E Gouaux - Nature structural & molecular biology, 2018 - nature.com
Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by
increasing the local concentrations of neurotransmitters at synapses and in extracellular …