The ErbB/HER family of protein-tyrosine kinases and cancer
R Roskoski Jr - Pharmacological research, 2014 - Elsevier
The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
The ERBB network: at last, cancer therapy meets systems biology
Y Yarden, G Pines - Nature Reviews Cancer, 2012 - nature.com
Although it is broadly agreed that the improved treatment of patients with cancer will depend
on a deeper molecular understanding of the underlying pathogenesis, only a few examples …
on a deeper molecular understanding of the underlying pathogenesis, only a few examples …
Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution
The oligomeric organization of membrane proteins in native cell membranes is a critical
regulator of their function. High-resolution quantitative measurements of oligomeric …
regulator of their function. High-resolution quantitative measurements of oligomeric …
The EGFR family: not so prototypical receptor tyrosine kinases
MA Lemmon, J Schlessinger… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
Structure and dynamics of the EGFR/HER2 heterodimer
X Bai, P Sun, X Wang, C Long, S Liao, S Dang… - Cell Discovery, 2023 - nature.com
HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its
overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 …
overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 …
Receptor tyrosine kinase activation: From the ligand perspective
Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which
relatively conserved intracellular kinase domains are coupled to divergent extracellular …
relatively conserved intracellular kinase domains are coupled to divergent extracellular …
Architecture and membrane interactions of the EGF receptor
Dimerization-driven activation of the intracellular kinase domains of the epidermal growth
factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways …
factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways …
EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with
seven different activating ligands shaping cell signaling in distinct ways. Using …
seven different activating ligands shaping cell signaling in distinct ways. Using …
A structural perspective on the regulation of the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
Differential sensitivity of glioma-versus lung cancer–specific EGFR mutations to EGFR kinase inhibitors
Activation of the epidermal growth factor receptor (EGFR) in glioblastoma (GBM) occurs
through mutations or deletions in the extracellular (EC) domain. Unlike lung cancers with …
through mutations or deletions in the extracellular (EC) domain. Unlike lung cancers with …