Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human
African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in …

Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …

Rheumatoid arthritis (RA) occurs in about 5 per 1,000 people and can lead to severe joint
damage and disability. However, the knowledge of pathogenesis and treatment for RA …

Schistosomiasis is a neglected disease of poverty that is caused by infection with blood fluke
species contained within the genus Schistosoma. For the last 40 years, control of …

Phenotypic screening is a powerful technique that allowed the discovery of antimicrobials to
fight infectious diseases considered deadly less than a century ago. In high throughput …

Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical
disease that affects more than 200 million people worldwide. There is only one drug …

Listeria monocytogenes (Lm) is a Gram-positive bacillus responsible for listeriosis in
humans. Listeriosis has become a major foodborne illness in recent years. This illness is …

Abstract Development of direct acting macrofilaricides for the treatment of human filariases is
hampered by limitations in screening throughput imposed by the parasite life cycle. In vitro …

To investigate the physicochemical properties of anti-schistosomal compounds reported
between 2008 and 2023, a simple but extensive literature scrutiny was conducted …

Interactions between the environment, parasites, vectors, and/or intermediate hosts are
complex and involve several factors that define the success or failure of an infection. Among …