Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Obesity is commonly associated with nonalcoholic fatty liver (NAFL), a benign condition
characterized by hepatic lipid accumulation. However, NAFL can progress in some patients …

Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic
and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor …

Lethality of coronavirus disease (COVID-19) during the 2020 pandemic, currently still in the
exponentially accelerating phase in most countries, is critically driven by disruption of the …

Transient receptor potential vanilloid 4 (TRPV4) is a non-selective mechanosensitive ion
channel expressed by various macrophage populations. Recent reports have characterized …

Lead-induced hepatotoxicity is characterized by an extensive oxidative stress. Grape seed
procyanidin extract (GSPE) possesses abundant biological activities. Herein, we …

Diabetic peripheral neuropathy (DPN) is caused by several factors, including reactive free
oxygen radicals (ROS)-induced excessive Ca2+ influx. Transient receptor potential (TRP) …

Metabolic-associated fatty liver disease (MAFLD), which is often linked to obesity,
encompasses a large spectrum of hepatic lesions, including simple fatty liver …

The transient receptor potential ion-channel superfamily consists of nonselective cation
channels located mostly on the plasma membranes of numerous animal cell types, which …

Scleroderma is a multisystem fibroproliferative disease with no effective medical treatment.
Myofibroblasts are critical to the fibrogenic tissue repair process in the skin and many …