Polyprodrug nanomedicines: an emerging paradigm for cancer therapy

K Yang, Z Yang, G Yu, Z Nie, R Wang… - Advanced …, 2022 - Wiley Online Library
Nanomedicines have the potential to provide advanced therapeutic strategies in combating
tumors. Polymer‐prodrug‐based nanomedicines are particularly attractive in cancer …

Research progress on self-assembled nanodrug delivery systems

L Qiao, H Yang, S Gao, L Li, X Fu, Q Wei - Journal of materials …, 2022 - pubs.rsc.org
In recent years, nanodrug delivery systems have attracted increasing attention due to their
advantages, such as high drug loading, low toxicity and side effects, improved …

Poly (disulfide) s: from synthesis to drug delivery

R Zhang, T Nie, Y Fang, H Huang, J Wu - Biomacromolecules, 2021 - ACS Publications
Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …

Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy

M Shi, J Zhang, Y Wang, C Peng, H Hu, M Qiao… - Biomaterials, 2022 - Elsevier
Multiple biological barriers and tumor metastasis severely impede the tumor therapy. To
address these adversities, an acid-activated poly (ethylene glycol)-poly-l-lysine-2, 3 …

[HTML][HTML] Advances and prospects of RAFT polymerization-derived nanomaterials in MRI-assisted biomedical applications

W Zhao, C Li, J Chang, H Zhou, D Wang, J Sun… - Progress in Polymer …, 2023 - Elsevier
Magnetic resonance imaging (MRI) is recognized as the most powerful clinical imaging
modality due to its ability to produce detailed three-dimensional anatomical images and high …

Near‐infrared light‐triggered polyprodrug/siRNA loaded upconversion nanoparticles for multi‐modality imaging and synergistic cancer therapy

G Kuang, H Lu, S He, H Xiong, J Yu… - Advanced …, 2021 - Wiley Online Library
Stimuli‐responsive nanosystems have been widely applied as effective modalities for
drug/gene co‐delivery in cancer treatment. However, precise spatiotemporal manipulations …

Fe3O4-Au Core-Shell Nanoparticles as a Multimodal Platform for In Vivo Imaging and Focused Photothermal Therapy

C Caro, F Gámez, P Quaresma, JM Páez-Muñoz… - Pharmaceutics, 2021 - mdpi.com
In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with
polyvinylpyrrolidone (Fe@ Au NPs). The as-synthesized nanoparticles (NPs) exhibited good …

Enzyme-triggered size-switchable nanosystem for deep tumor penetration and hydrogen therapy

Y He, X Tian, X Fan, X Gong, S Tan, A Pan… - … Applied Materials & …, 2023 - ACS Publications
The poor penetration of nanocarriers within tumor dense extracellular matrices (ECM)
greatly restricts the access of anticancer drugs to the deep tumor cells, resulting in low …

Multifunctional nanosystems powered photodynamic immunotherapy

Y Ma, F Xiao, C Lu, L Wen - Frontiers in Pharmacology, 2022 - frontiersin.org
Photodynamic Therapy (PDT) with the intrinsic advantages including non-invasiveness,
spatiotemporal selectivity, low side-effects, and immune activation ability has been clinically …

Camptothecin-based prodrug nanomedicines for cancer therapy

H Jiang, RS Zhang, C Wang, J Yu, Z Guo - Nanoscale, 2023 - pubs.rsc.org
Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication cancer cells via
blocking DNA topoisomerase 1. Despite its encouraging and wide spectrum antitumour …