A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …
S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …
They are widely used in a variety of pharmacological and industrial applications. Their …
Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico …
HA Elsebaie, EA El-Bastawissy, KM Elberembally… - Bioorganic …, 2023 - Elsevier
The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
Medicinal perspective of a promising scaffold–dihydropyrimidinones: A review
BH Sarvaiya, PI Vaja, NA Paghdar… - Journal of Heterocyclic …, 2024 - Wiley Online Library
Dihydropyrimidinones (DHMPs) are the most important pharmacophore in Medicinal
Chemistry. The synthetic approach for deriving DHMPs involves the Biginelli reaction or a …
Chemistry. The synthetic approach for deriving DHMPs involves the Biginelli reaction or a …
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
[HTML][HTML] Synthesis, evaluation of the cytotoxicity, apoptosis induction in AGS cell line and gene expression and molecular modeling studies of novel …
Cancer is a complex disease that remains a leading cause of death worldwide owing to the
lack of effective and efficient drugs. Compounds known as tetrahydropyrmidine have shown …
lack of effective and efficient drugs. Compounds known as tetrahydropyrmidine have shown …
Revisiting ageless antiques; synthesis, biological evaluation, docking simulation and mechanistic insights of 1, 4-Dihydropyridines as anticancer agents
PA Sidhom, E El-Bastawissy, AA Salama… - Bioorganic …, 2021 - Elsevier
The historic DHP nucleus was serendipitously discovered by Arthur Hantzsch about 130
years ago and is still considered a hidden treasure for various pharmacological activities …
years ago and is still considered a hidden treasure for various pharmacological activities …
Negative modulation of the angiogenic cascade induced by allosteric kinesin Eg5 inhibitors in a gastric adenocarcinoma in vitro model
A Ricci, M Gallorini, D Del Bufalo, A Cataldi… - Molecules, 2022 - mdpi.com
Eg5 is a kinesin essential in bipolar spindle formation, overexpressed in tumours, thus
representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity …
representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity …
Design, synthesis, molecular dynamics simulation, MM/GBSA studies and kinesin spindle protein inhibitory evaluation of some 4-aminoquinoline hybrids
SD Ranade, SG Alegaon… - … Biology and Chemistry, 2023 - Elsevier
The discovery of novel chemotherapeutic agents is always challenging for researchers in
industry and academia. Among the recent promising anticancer therapeutic targets, an …
industry and academia. Among the recent promising anticancer therapeutic targets, an …
Synthesis of substituted hexahydro-2H-chromeno[4,3-d]pyrimidine-2,5-diones and their modification at the hydroxy group
ES Makarova, MV Kabanova, SI Filimonov… - Russian Chemical …, 2022 - Springer
Synthesis of substituted hexahydro-2H-chromeno[4,3-d]pyrimidine-2,5-diones and their
modification at the hydroxy group Page 1 Russian Chemical Bulletin, Vol. 71, No. 5, pp …
modification at the hydroxy group Page 1 Russian Chemical Bulletin, Vol. 71, No. 5, pp …
Microwave-accelerated multicomponent synthesis and X-ray characterization of novel benzothiadiazinone dioxide derivatives, analogues of Monastrol
We demonstrate here a rapid and comfortable synthetic sequence to benzothiadiazinone
dioxide (six-membered cyclic sulfamide) derivatives, analogues of Monastrol, which is …
dioxide (six-membered cyclic sulfamide) derivatives, analogues of Monastrol, which is …