Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Emerging evidence indicates that gut microbiota is important in the regulation of brain
activity and cognitive functions. Microbes mediate communication among the metabolic …

Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual's motivation to engage in physical activity remain …

Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Background Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly.
Although the concept of the gut–muscle axis has been raised, the casual relationship is still …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

Evidence suggests that gut microbiota composition and diversity can be a determinant of
skeletal muscle metabolism and functionality. This is true in catabolic (sarcopenia and …

Gut microbiota refers to those microorganisms in the human digestive tract that display
activities fundamental in human life. With at least 4 million different bacterial types, the gut …

A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …