Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …

The term acute liver failure (ALF) is frequently applied as a generic expression to describe
patients presenting with or developing an acute episode of liver dysfunction. In the context of …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Abbreviated pathogenesis and clinical course of the acute liver failure syndrome. The
pathogenesis and clinical course of the syndrome of acute liver failure (ALF) differs …

Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a
centrilobular hepatic necrosis that can be fatal. Acetaminophen poisoning accounts for …

Acetaminophen (APAP or paracetamol or N-acetyl-p-aminophenol), a safe and effective
antipyretic and analgesic, has been extensively used around the world since 1955. It is …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …